Saturday, March 7, 2020

Sports and Steroids Societys Acceptance or Rejection of Steroids in Sports

Sports and Steroids Societys Acceptance or Rejection of Steroids in Sports Introduction The essence of all athletic competitions can be boiled down to the concept of performance and how much better one particular athlete is over another. Professional athletes do not enter into a competition with a nonchalant attitude of competing for fun rather they are in it to win it and as such train endlessly in order to reach the peak of their physical prowess.Advertising We will write a custom research paper sample on Sports and Steroids: Society’s Acceptance or Rejection of Steroids in Sports specifically for you for only $16.05 $11/page Learn More Their reward for winning such competitions can range from money, fame to everlasting glory in their chosen sport. Unfortunately, there are no rewards for the losers with society relegating them to the background as they celebrate the accomplishments of the winners. It is due to this that athletes try to accomplish any means possible to win with some of them choosing shortcuts in their attem pt to achieve money, fame and glory. One of the shortcuts comes in the form of using anabolic steroids in order to boost muscle performance in order to give them a certain edge over the competition. It has been proven through both clinical tests and actual usage in sporting competitions that the use of steroids significantly increases muscle density, strength, reduces recovery time and drastically increases an athlete’s stamina (Hassan, Salem Sayed, 2009). While their effectiveness has been proven time and again their usage in sporting competitions has been categorized as a form of cheating. Normal athletes cannot rival the performance of other athletes on steroids and as such it comes to a point that they either have to take steroids themselves or not compete at all. This creates a situation where it is not the best athlete that wins in a competition but rather which athlete has used steroids the most in order to win (Mannie, 2004). Such activities can be considered a clear violation of the concept of fair play and is affront to spirit of competition. The general public has thus responded negatively to the use of steroids in sporting competitions since people do not patronize sports such as baseball, football or soccer in order to watch people cheat their way into victory rather they watch sporting events in order to see the clash of individuals striving to achieve victory through the power of effort, willpower and the spirit to succeed. What must be understood is that the concept of a person being an athlete has a special meaning in society in that they represent what a person can achieve should they work hard, strive for success and never give up. Athletes have in effect become role models for many within society and as such news of prolific cheating by numerous athletes within sporting events is generally considered a form of betrayal over the image of integrity, willpower and perseverance that society has attached to them. As such it comes as no s urprise that the various steroid scandals that have rocked numerous sports over the past several years have detrimentally affected their fan bases and made fans that much more suspicious and hesitant over patronizing a particular team or athlete on the basis that they may be using steroids to cheat their way to victory.Advertising Looking for research paper on health medicine? Let's see if we can help you! Get your first paper with 15% OFF Learn More It is based on this that the scope of this paper will entail an investigation into society’s reaction to the use of steroids and examines the negativity surrounding this particular form of controversial enhancement. Furthermore the goal of this paper will be an attempt to convince audiences that steroids should not be used for advancement in sports and that they are a bad influence on adolescents. Comparing and Contrasting an Athlete’s Decision to Take Steroids and the Perception of Fans. Decision for Taking Steroids When trying to understand why an athlete would take steroids it must first be acknowledged that not all people are born equal. Some people have genetic predispositions towards athleticism which does give them a certain advantage over other athletes. Another factor that should be taken into consideration is the fact that similar to any profession being an athlete requires a certain degree of performance above set standards in order to be acknowledged by the general public. It can be seen that athletes that rise above the norm often attain lucrative sponsorship agreements, team contracts and a plethora of other benefits befitting an athlete of their caliber. On the other hand athletes that are sub-par or fail to distinguish themselves often fade into obscurity or are relegated to contracts and sponsorships that are barely within the range of the average median salary within the U.S. Not only that unlike other careers athletes only have a set period of time in order to stand out and distinguish themselves due to decreasing performance levels as they age. Steroids give athletes the performance boost they need in order to win games, events or sporting competitions (Mannie, 2004). It enhances their stamina, gives them greater strength, speed and durability and even allows them to recover faster from injuries thus resulting in a performance level that is above the norm (Silvester, 2006). What must be understood is that modern day sporting competitions whether in baseball, football or basketball are all about a players stats and playing ability. The value of athletes has been relegated to a set of numbers wherein the greater the number the higher their value is to a team or sponsors. This creates a behavioral predilection towards constant improvement towards perfection not for the sake of being more competitive but rather a desire to stay relevant in sporting events where superstars abound and talented rookies enter into the fray on an almost yearl y basis. Steroid Use among Athletes In a way being an athlete is a race against time as they fight to stay relevant whiles their bodies age and their abilities whither. What must be understood is that steroid use helps to preserve and enhance existing skills beyond what people would normally be capable of doing.Advertising We will write a custom research paper sample on Sports and Steroids: Society’s Acceptance or Rejection of Steroids in Sports specifically for you for only $16.05 $11/page Learn More It acts as a method of increasing muscular density and stamina resulting in increased performance in even the oldest athletes (Silvester, 2006). One example of this can be seen in increased performance of Barry Bonds during the latter part of his career. What must be understood is that while Barry Bonds was an excellent baseball player in his youth however his performance started to decline during his early 30s. Surprisingly though Bonds very noticeably began to bulk up and his performance greatly improved during his mid 30s to the point that he was noticeably better than he was during the earlier half of his career. As it turns out his improved physique and athletic prowess were not due to a strenuous workout regimen and diet as Bonds had stated but rather was entirely due to steroid use. Other baseball athletes that exhibited greater athleticism during the latter part of their careers such as Sammy Sousa have also tested positive for steroid use and as such its use has become synonymous with cheating the clock so to speak wherein physical prowess and athletic performance is preserved or even drastically improved during the latter part of an athletes career. It is due to this that athletes begin to turn towards steroid use in order to not be relegated into the background, to achieve their moment of fame, to preserve their athleticism when theyre well past their prime and to attain in their eyes their much deserved reward for stri ving so hard. Perception of Steroid use by Fans and Athletes On average fan perception regarding steroid use by athletes has been largely negative with most athletes that have proven records of steroid usage often losing a majority of their fans (Denham, 2000). As it was indicated earlier athletes are often used by society as role models for behavior and achievement. When such athletes cheat in order to win it is thought of as being the equivalent of spitting in the face of the people that believed in them for so long. People want to believe that incredible feats of athleticism are possible through hard work and perseverance since for them it is a reflection of what they themselves might be capable of in their own lives albeit in a different way. It must be noted though that before they are found out athletes that use steroids often have a much larger fan base as compared to athletes that dont use steroids. This is due to the fact that their improved performance often makes them mor e prominent as compared to other athletes and as such become fan favorites. It is only when they are found out that their fan base rapidly erodes and such athletes are thought of in a negative light due to their use of unethical methods in order to boost their performance.Advertising Looking for research paper on health medicine? Let's see if we can help you! Get your first paper with 15% OFF Learn More In general it can be seen that both in society and in the media athletes that use steroids are generally portrayed unfavorably due to them representing the darker half of sports (Denham, 2000). They are vilified, thought of as cheaters and sometimes even shunned for their actions and as such can be considered a warning to all athletes that even consider turning to steroids as a means of boosting their performance. Adolescents and Steroids What is the percentage of adolescent users? An examination by the National Institute of Drug Abuse (NIDA) estimates that within the U.S. alone nearly 500,000 teenagers are currently using steroids (Kuehn, 2009). In fact it was noted by Kuehn (2009) that in 2005 there was a .7% increase in the amount of steroids utilized by boys in 10th grade as compared to the previous year which was at only 2% (Kuehn, 2009). What must be understood is that while 2.7% may seem like small number the fact remains that no teenager should be using steroids at all so ev en a .7% increase can be considered a large increase. It as estimated that nearly 6.6% of all male high school seniors particularly those within athletic programs utilized steroids in order to gain a competitive edge (Kuehn, 2009). Further studies also revealed that there was also a certain degree of steroid use among the female athletes within various high schools but little data has been collected regarding this particular population base due to the fact that most studies focuses on male archetypes of steroid usage. It is interesting to note though that there are no racial differences in steroid use with no specific racial group specifically utilizing steroids. What was seen though is that steroid use was often concentrated in various athletic departments and as such in order to examine the prevalence of steroid use in a particular school it is best to focus most of the examinations mainly on student athletes since they have a greater predilection towards its use. What must be und erstood is that steroid usage has a specific risk factor for adolescents as compared to adults due to the fact that rising testosterone and sex hormone levels within the body are actually used as an inherent mechanism for triggering growth spurts during adolescence. When these hormone levels reach a certain point they actually send a signal to a persons bones to stop growing and unfortunately by utilizing anabolic steroids this causes the bones to stop growing prematurely for adolescents (Bahrke,Yesalis, Kopstein Stephens, 2000). This particular situation is also facilitated by other side effects of steroids such as increased aggression, the development of liver tumors, cholestatic jaundice and in some cases the development of blood filled cysts within the liver that have a tendency to rupture causing internal bleeding (Lumia McGinnis, 2010) Adolescents, Peer Pressure and their Emulation of Sports Icons What must be understood when examining the current behavior of numerous young adolescents and their use of steroids is the fact that they believe steroids are an effective shortcut of enhancing their performance to the same degree as their sports heroes. While it may be true that they acknowledge the fact that taking steroids is a form of cheating they still look at athletic greats such as Sammy Sosa, Barry Bonds, Triple H and Batista who have all been confirmed as taking steroids and believe that despite the inherent risks involved the glory, money and fame that comes along with being an athletic superstar is well worth the risks involved in utilizing steroids (Feinberg, 2009). Furthermore the persistent myth that side effects only come through prolonged usage convinces many student athletes that by taking steroids in limited amounts they can avoid the supposed side effects that come with steroid use. Another factor that should be taken into consideration is peer pressure and how it at times forces people to take steroids even though they initially have no d esire to. A student athletes’ worth is determine by their performance in their given sport and at times such students are pressured into taking steroids by their teammates in order to improve their performance and win championships. Even though they dont want to take steroids the pressure to perform and be part of the team often causes young athletes to take steroids which places them on the path for future health complications in the future. Conclusion Based on what has been presented in this paper so far it can be seen that steroid usage among athletes not only is a highly unethical method of competing within a sport but it also sends the wrong message to adolescents that all they need to do in order to become a sports superstar is to take steroids. While it may be true that steroids do indeed boost athletic performance to considerable levels the fact remains that in the end if such athletes are found out they tarnish the reputations of the sport and ruin the sense of fair play and competition that is the basis for most sporting events. Not only that the rising rates of adolescent steroid usage can be assumed as being directly connected to steroid usage within major sports as well and as such players that use steroids can be considered ethically liable for health conditions adolescents that take steroids will suffer since they act as their role models. It is based on the findings of this paper that it can be stated that steroids should not be used for advancement in sports due to both the negative reputation it gives to certain sports and the fact that adolescents look up to their sports heroes as the basis for their own attitude in competitive events. Reference List Bahrke, M. S., Yesalis, C. E., Kopstein, A. N., Stephens, J. A. (2000). Risk Factors Associated With Anabolic-Androgenic Steroid Use Among Adolescents. Sports  Medicine, 29(6), 397-405. Retrieved from EBSCOhost. Denham, B. E. (2000). Performance-Enhancing Drug Use in Amateur and Profes sional Sports: Separating the Realities from the Ramblings. Culture, Sport, Society, 3(2), 56. Retrieved from EBSCOhost. Feinberg, J. M. (2009). College Students Perceptions of Athletes Who Cheat: The Role of Performance and History. Journal of Sport Behavior, 32(4), 460. Retrieved from EBSCOhost. Hassan, N. A., Salem, M. F., Sayed, M. L. (2009). Doping and effects of anabolic androgenic steroids on the heart: histological, ultrastructural, and echocardiographic assessment in strength athletes. Human Experimental  Toxicology, 28(5), 273-283. Retrieved from EBSCOhost. Kuehn, B. M. (2009). Teen Steroid, Supplement Use Targeted. JAMA: Journal of the  American Medical Association, 302(21), 2301. Retrieved from EBSCOhost. Lumia, A. R., McGinnis, M. Y. (2010). Impact of anabolic androgenic steroids on adolescent males. Physiology Behavior, 100(3), 199-204. Mannie, K. (2004). DESIGNER STEROIDS: UGLY, DANGEROUS THinGs. Coach   Athletic Director, 73(9), 14. Retrieved from EBSCOhost . Silvester, J. L. (2006). ANABOLIC STEROIDS AT THE 1972 OLYMPICS!. Coach   Athletic Director, 76(3), 11. Retrieved from EBSCOhost.

Thursday, February 20, 2020

Social responsibility in finance decision making Essay - 2

Social responsibility in finance decision making - Essay Example cture, McDonalds focuses its attention to putting its customers, processes, and practices into place to better the society through better food, people that are more contented, a stronger community, and an improved planet. This report explores McDonalds’ Corporate Social Responsibility approach in finance decision making. McDonalds, the worlds foremost global food service trader, takes its environmental and social obligation to the society considerably seriously, considering the CSR strategies it partakes. The company consults with customers, suppliers, sustainability experts and socially responsible organizations to ensure that its CSR strategies are in lieu with the current century and societal goals. It collaborates with other organizations to develop global principles that support purchase of raw materials from verified sustainable sources. This paper explores McDonald’s practices, their harm to the society, and CSR initiatives it has taken to promote its corporate image. In as much as a company seeks to make profit in a sustainable approach, there are always times when they inflict harm on one or more of its stakeholders for profit making. McDonalds faces criticism for the level of nutrition in its food, which is largely high fat, high cholesterol, low fiber diet. It also receives criticism for the effects of advertisements on the minds of children, and the environmental effects of its restaurants on the environment. Considering McDonalds is among the world’s leading companies it has the financial and legal muscle to silence its critics and limits free speech against its operations (Blasio, 2008). Apart from that, workers claim exploitation in several instances, especially in branches comprised of underprivileged people. Workers receive low wages, and understaffing also occurs, as the company seeks to maximize on profits. Worst of all, its aggressive practices push several small food outlets out of business (Brazelton, Ellis, Macedo, Shader, and Suslow,

Tuesday, February 4, 2020

Understanding public relations theory Essay Example | Topics and Well Written Essays - 1500 words

Understanding public relations theory - Essay Example Change Management Communication In addition, the role of mass media as an agent of communicating organizational intentions and promotion of interest can also not be ignored by organizations. Overall, the understanding and appreciation of the various approaches, theories and other related concepts of public relations is important in tackling of issues or concerns that may arise from daily operations. In response to this, this paper will examine the role of public relations practice in organizations. For applicability, the paper has identified the issue of change management communication in organizations. This will be examined through a selected article about an organization that is likely to be affected by the subject matter of discussions in this paper. The paper will discuss the components of the article that make it a media issue as well as a public relations issue. The article under examination pertains to Boral Company that operates in the building and construction industry. The company’s new chief execu tive having taken the reign in the top leadership has been tasked with a challenge of ensuring that the company’s financial results improve as a result in an economy downfall that has affected the construction industry in which the company operates in. One of the measures that the chief executive has been compelled to take after a 100 day review is through initiating a 700 job cut program targeting management and back office staff. Even though the move is likely to cost the company a massive 60 million dollars, if successfully implemented it has been projected to result to an annual saving of about 90 million dollars. However, the major issue that arises from this situation is that of how to effectively manage this drastic change especially by communicating the intended purposes and criteria for such changes to the stakeholders of the company that will be largely affected by this decision (Hayes, 2006). Consequently, the main purpose of the following discussions will be to an alyze the contributions that public relations, which can be stated to be constituted of communication with external and internal publics, and communication management, can make in managing organizational change during an employee retrenchment exercise. The framework that will be used to analyze the situation at Boral will be in terms of a dual examination of the issue in terms of being a media as well as a public relations issue. To begin, as a media issue, the organization needs to be prepared to tackle several issues so that the image of the firm remains intact in the eyes of the public. The media plays a major role in shaping opinions and the issue of job cuts proposed by the new chief executive can result into an image backlash if not well handled. It is the job of the public relations professionals and the department in charge of the area affected, in this case the board of governors through the chief executive officer and to some extent the human resources, to learn the facts and information needed, and communicate it to the targeted audiences in a timely and effective manner. The organization's reputation and credibility with external and internal audience is at stake. This is because tackling the issue of job cuts at a time when the economy is hard an issue for the whole nation is a sensitive and important issue. Whatever is communicated internally and externally will remain forever on

Monday, January 27, 2020

Quantitative investigation of immunoglobulins

Quantitative investigation of immunoglobulins Introduction- Quantitative investigation of Immunoglobulins is the basis of the standard laboratory technique within the field of clinical immunology. Immunoglobulins can be measured quantitatively through the use of nephelometry, such measurements are vital in the instance of a suspected immunodeficiency within a patient. For this reason the test is accurate and rapidly measures the amounts of IgM, IgG and IgA proteins within the blood of the patient and from such determine if a number of conditions or disorders are present. The role of such antibodies is within fighting infections and allergies as part of the normal immune response. A disease (or disorder) can be identified through the measurement of such protein levels. IgM for example can appear during an initial infection and then reappear to a lesser extent upon secondary exposure. (Weir, 1978) Nephelometry is usually performed by drawing blood from a vein on the back of the hand or if not possible the inside of an elbow. The needle draws the blood into an airtight vial or tube attached to it. Removal of the needle is followed by sterilisation and covering of the incision site. (Stanley, 2002) Practical Schedule- Nephelometry is an automated system that measures antigen or antibody solution in very limited concentrations by the amount of light scatter. The principle is that when the light comes into contact with the solution it will not be absorbed but scatter away from the main beam and measured at angles between 0-90 from a predefined curve. The subsequent amounts are proportionate to that of the concentration of molecules. As well as dilute solutions there also needs to be a linear correlation between molecules formed and optical density. For this reason several dilutions measurements are recorded and also during the formation of molecules. This process is known as rate nephelometry. When considering this technique it is vital that the relative amount of antigen and antibody must be small enough so that precipitation does not occur but also large enough to allow the formulation of small immune complexes. Immunoprecipitation results are achieved through the use of monoclonal antibodies (MCAs) allowing epitopes to react with the antiserum and MCAs forming immune precipitates with their antigens. Results- Normal results IgG: 560 to 1800 mg/dL IgM: 45 to 250 mg/dL IgA: 100 to 400 mg/dL Evaluation- the automated nature of this technique means that it is both fast accurate with results available within 1-2 hours. Its wide spread use is mainly down to this factor but its simplicity and low sample size and volumes also make it a valued technique with the clinical laboratory setting. (Diamandis et al1996). It is however, as with most techniques not without its draw backs. The usual precautions should be taken as when taking any blood sample. Although rare excessive bleeding, fainting and infection should all be considered as risk factors when taking samples. (Drexel, 14/06/08) The presence of dust particles and other debris can be cause for distorted readings and lead to higher values than expected. This can be addressed through centrifugation of the specimen (Diamandis et al1996). In addition to this air bubbles can cause similar effects on results. To ensure readings are as accurate as possible, the specificity should be at optimum level, as set on the nephelometer and controls should be carried out wherever it is used. (Palmer, 1992) Although this method does determine the amount of each immunoglobulin it does not possess the ability to identify antibodies. Another method that can be used to quantitatively investigate Immunoglobulins in serum, saliva, cerebrospinal fluid (CSF), amniotic fluid, and gastrointestinal juice is Radial Immunodiffusion (Chapel et al1999). This technique allows for the adding of a sample to a well in a gel made up of the antibody specific for the substance being tested for. This then moves through the gel leading to the formation of a visible precipitate around the optimum concentration sample well. The interpretation of such results however is subjective and results are delayed as the process takes several days and as such nephelometry is recommended for greater precision, automation, objectivity and speed and is suitable for large throughput tests (Keogan et al 2006). It is also hard to quantitatively analyse the results using very small samples and a calibration curve. (Chapel et al., 2006). 2. Quantitative Other Serum Proteins-Radial Immunodiffusion Introduction Radial Immunodiffusion acts upon the antigen- antibody complex precipitation reaction. It is used within the field of neurology and oncology. This involves passive diffusion of immunoreactants through an agar matrix. An electrical current is not required for such process to occur as is reliant upon the physiochemical relationships. Practical Schedule Radial Immunodiffusion works via the mixing of antiserum with agar and pouring it on a glass plate to allow it to solidify. The antiserum must be specific for the class of immunoglobulin that is being measured for the technique. The agar mixture is then punctured and the subsequent holes filled using the sera from the test samples. Diffusion of the Immunoglobulins radially causes the formation of precipitate at the point which the number of antibody and antigen are identical. As with previous techniques a calibration curve us used that has been made up from known set of solution to determine the amount of Immunoglobulins present within the sample. Evaluation Accuracy and specificity is the most potent threat to validly of this technique. The fundamental problem is the lack of sensitivity and is not a rapid technique with results taking over 48 hours owing to reaction times. (Chapel, 2002) Whilst it does provide use in the determination of serum proteins quantitatively there are an array of factors that can lead to unreliable results. Temperature of the gel and external environment, molecular size, gel viscosity, reactant concentration and buffer pH highlights a few of the factors that will affect the rate of diffusion but is not exhaustive. (Nakamura et al, 1979) 3. Quantitative other Serum proteins Collection of serum Collect blood in a glass container and allow it to clot at room temperature for an hour. Once the clot has formed loosen the walls of the container to aid retraction. Transfer to 4 degrees and leave overnight if necessary Collect the expressed serum and centrifuge at 150g for 5 minutes to sediment the erythrocytes, and then at 350g for 15 minutes. Transfer the straw coloured serum to suitable containers and heat at 56 degrees for 30 minutes to destroy the heat labile components of complement. (Hay et al., 2002) Qualitative Immunoglobulins Introduction- The stages of diagnosis, determination of immunity and the susceptibility of an individual to many microbial infections, are based upon immunological tests in serum. When blood clots the fluid that remains is known as serum and as such it is rich in Immunoglobulins. Serum however is not easily accessible so other sample sources can be used. The presence of specific Immunoglobulins in urine, saliva and cerebrospinal fluid mean that such bodily fluids, inclusive of others such as semen, can be used instead. Anatomically the most readily available and less intrusive however, as with other bodily fluids, contain low concentrations of IgM and IgG. Semen is abundant with these Immunoglobulins and as such may be perceived as being the most accurate and reliable in any such investigations (PCT, 1987) In Serum- Immunoelectrophresis Introduction- Serum Protein Electrophoresis is a qualitative investigation carried out to test for the presence of monoclonal bands (paraproteins). (Chapel et al., 2002) During electrophoresis, discrete monoclonal bands may appear (M bands). Further investigation is needed in order to determine the immunoglobulin heavy and/ or light chains through immunofixation. This is important when trying to distinguish what sort of Immunoglobulins are present. Determination is achieved through Immunoprecipitation in a gel with anti- sera that is specific for heavy and light chains of the immunoglobulin. Immunoelectrophresis works by separating sera in agarose gel by electrophoresis. Troughs that are parallel to the unfixed electrophoretic strips have specific anti- sera added to them leading to the formulation of precipitin arcs that are clearly visible owing to the process of diffusion. Immunofixation however tends to be more commonly used and as such will be more focused upon within the portfolio. This technique is commonly used in the diagnosis of conditions such as osteoporosis. In the abnormal absence of a heavy chain and an abnormal reaction occurring with the ant- sera that are specific for light chains discrete (M) bands are present. It is also a highlight to the possibility of an IgD or IgE paraproteins although is far less common. If an abnormal reaction occurs with only the heavy chain anti sera it is indicative of a rare heavy chain disorder. It is possibly to quantify individual M bands with the use of a densitometer. This acts by measuring the intensity of the stain taken up by each individual band and as such is the only method at present to be of use in the measurement of paraproteins concentration (Chapel et al1999). Practical Schedule taken from Clinical Immunology. (Chapel et al., 2002) Immunoelectrophoresis- Apply serum samples to an electrophoresis gel at the cathode end alongside a normal serum sample as a control. Apply an electric current for 45 minutes and remove the gel. Use a stain to visualize the bands. Immunofixation-specific antisera to IgG, IgA, IgM and kappa and lambda light chains are then applied to the electrophoresed samples by soaking strips of cellulose acetate in the individual antisera and laying them on the electrophoresis gel. This is then incubated for 2 hours and all the un-fixed proteins are washed off leaving the precipate. Individual monoclonal bands can be quantitatively measured by a densitometer. Results The dark areas indicate monoclonal bands. The picture above shows a positive result for the lambda chain. The presence of monoclonal bands can indicate multiple myelomas or osteoporosis. In this example, the M band is identified as IgG of kappa type. Concentration of the M band is determined using a densitometric trace, as demonstrated in the second image. Evaluation- The presence of air bubbles will distort the formation of protein bands and as such the gel must be degassed. The method detailed above is much quicker and far more sensitive than the singular use of immunoelectrophresis. Its cheapness and low hazard level mean it is a desirable technique in the detection of Immunoglobulins within serum. (Zola et al. 1999) Qualitative Immunoglobulins in Urine- Electrophoresis and Immunofixation Normal physiology of the kidney dictates that protein is usually excreted within the urine in minimal amounts. Higher levels can lead to the suspicion of multiple myeloma that can lead to irrapairable damage to the kidneys as nephritic cells are non replaceable with chronic lymphocytic leukaemia and hypogammaglobulninaemia being suspects. Kidney disorders such as IgA nephropathy may also be a causation of such symptoms. All humans produced excessive amounts of free polyclonal light chains in accompaniment to normal immunoglobulin synthesis with these being secreted into the urine and are detectable in low amounts in all samples (Thompson, 1981). If the normal range of this is exceeded however it is indicative of renal damage. This method is often used in order to detect these small free monoclonal light chains that are also called Bence- Jones Proteins owing to the fact that normal parameters of testing fail to pick them up. (Chapel, 2005). Bence- Jones Proteins are distinguishable by the fact they possess unusual thermal properties, for example they precipitate out of the urine solution at 56 degrees and redissolve upon further heating. (Thompson, 1978) Practical Schedule Determine concentration by ultrafiltration, absorption of water, or by freeze-drying. There are several commercially available kits for determining the concentration of urine. This involves concentrating the urine, then using electrophoresis to determine the presence of monoclonal bands. Then using immunofixation to establish what the monoclonal band is made of. (Chapel et al., 2006) Results Serum protein samples from patients with light chain multiple myeloma and one normal result on the far left.The M protein is seen as a dark dense band localised on the strip, this picture shows the different bands that can be detected. Albumin Decreased with malnutrition and malabsorption, pregnancy, kidney disease (especially nephrotic syndrome), liver disease, inflammatory conditions, and protein-losing syndromes Increased with dehydration Alpha1 globulin Decreased in congenital emphysaema (a1-antitrypsin deficiency, a rare genetic disease) or severe liver disease Increased in acute or chronic inflammatory diseases Alpha2 globulin Decreased with hyperthyroidism or severe liver disease, haemolysis (red blood cell breakage) Increased with kidney disease (nephrotic syndrome), acute or chronic inflammatory disease Beta globulin Decreased with malnutrition, cirrhosis Increased with hypercholesterolaemia, iron deficiency anaemia, some cases of multiple myeloma or MGUS Gamma globulin Decreased variety of genetic immune disorders, and in secondary immune deficiency Increased Polyclonal: chronic inflammatory disease, rheumatoid arthritis, systemic lupus erythematosus, cirrhosis, chronic liver disease, acute and chronic infection, recent immunization. Monoclonal: Waldenstroms macroglobulinaemia, multiple myeloma, monoclonal gammopathies of undetermined significance. (MGUS) Table from lab tests UK online. Evaluation-this method allows the determination of the different proteins in the urine and can be vital in allowing the doctor to work out a diagnosis of the condition. It is relatively simple and reliable however the results can only be read by a skilled worker and owing to its various steps is not as rapid as desired. Results show that different diagnoses are reached depending on which Immunoglobulins are increased in the urine, as indicated in the table above. Qualitative Immunoglobulins in Cerebrospinal Fluid- immunoperoxidase and isoelectric focusing This test allows for the differentiation between IgG and albumin concentrations. This relationship is important to differentiated as IgG is synthesised by lymphocytes within the brain where as albumin is not and is known as the CSF IgG Index that is indicative of this fact as demonstrates how much IgG within the CSF has been synthesised. (Chapel et al2006). Unlike the before mentioned serum where single discrete (M) bands where formed the locally synthesised IgG is often oligoclonal and subsequently cannot be detected by means of electrophoresis of CSF as isnt concentrated. (Roitt et al.. 2002) The only available method for the detection of oligoclonal bands are isoelectric focusing and immunofixation with enzyme labelled antiserum. Investigation and diagnosis of demyelinating disorders such as Multiple Sclerosis is carried out using such tests. (Richard et al 2002) Practical Schedule- Isoelectric focusing and immunofixation with enzyme labelled antiserums. This involves separating the proteins within a pH gradient and transferring them to nitrocellulose membranes that have previously been immunofixed with IgG antiserum to show the specific bands. This can be compared with controls to determine the new bands. (Richard et al., 2002) Results A positive result is where the oligoclonal IgG bands are not found in serums, but, in Cerebrospinal Fluid. These are shown as dense dark bands on the results below. 5-10% of CSF protein tends to be IgG. If a patient has disseminated sclerosis or sub-acute sclerosing panencephalitis then the proportion of IgG in CSF is over 12%. Evaluation This is a relatively modernised method and is approved for use within a clinical setting. The older isoelectric focusing is no longer recommended as it possesses a higher degree of specific (95%) and sensitivity. In addition it is favourable as only requires low concentrations of serum samples and results are available within 2 hours and mostly work on an automated level. (Richard et al.. 2002) Qualitative Immunoglobulins in Saliva- Complement- components Introduction Complement components are large molecular weight proteins. Activation of these usually results in proteolytic cleavage of the molecule into fragments. (Thompson, 1978) Western blotting is used in combination with gel electrophoresis and ELISA and RIAs are used when a whole saliva sample is collected or when there are saliva fractions [Fabian et al., 2007]. Practical Schedule- Gel filtration is carried out on Sephadex G-200. Serum samples of 1.5ml were applied to and 2.5cm diameter, 40 cm length column containing the Sephadex. This is equilibriated with a buffer containing 0.14M NaCl, 0.006M NaH2PO4 and 0.035M Na2HPO at a pH value of 7.3. Fractions of 2.5ml each are collected at a flow rate of 30ml per hour and the protein content of this effluent is measured as UV transmission at 280m µ in an absorbiometer. Results the results are determined by using these filtrated samples and single radial diffusion, a calibration curve is needed to determine amounts. This is created by using standard solutions. (Rose et al., 1997) Evaluation Occur in large amounts in serum can be measured accurately precipitin reaction in gel. Detecting them as antigens however means it cannot be identified as to whether they are active or not. Collecting specimens for complement assays can be difficult as you are to avoid inducing the complement pathway. Care should be taken to avoid false results caused by this when trying to determine the activation that was caused in vivo. Single radial diffusion can be used to determine quantitatively. This test is rapid reliable and easy to carry out and determine results of. (Rose et al., 1997) Complement-breakdown products Complement-C3- Crossed immunoelectrophoresis Introduction The complement system comprises of proteins (which may be membrane bound or present in plasma) that play an important role is host defences [Stanley, 2002]. The system is involved in destroying certain bacteria and viruses, and is also involved in initiating inflammatory response. Complement is also important for opsonisation of foreign materials, facilitation of phagocytosis by leukocytes, and direct cytotoxic reactions [Gaspari Tyring, 2008]. A determinant of the amount of C3 is crossed immunoelectrophresis and has the advantage of differentiating between inactive and active forms of C3. Deficiencies in C3 can lead to systemic infections including sepsis meningitis, pneumococcal and influenza infections. Method First dimension Prepare a 2% agarose solution in the barbitone buffer containing EDTA (ethylene diamine tetra-acetic acid) Pour 3 ml of agarose solution onto the microscope slide and let set. Cut a 1mm well in the slide removing the agarose and filling with the serum sample for the C3 quantification. Apply a potential difference of approx. 150v for 2 hours. Cut a 5 mm wide longitudinal strip containing the sample. Second dimension Prepare 12ml of an anti-C3 solution in 2% agarose solution at 56 degrees. Place the agarose strip at one end of the square glass plate and cover the whole slide with the agarose containing the anti-C3. Place the plate in the electrophoresis tank making sure it is the right way and electrophorese overnight. Wash and stain the precipitin arcs. This method works by using the electric field to separate the complement components. Results Evaluation- as with many of the before mentioned techniques it requires a skilled technician in order to carry out such a test and can edge on the side of time consuming owing to its numerous steps and incubation periods set out in the methodology. (Hay et al.. 2002) Complement- nephritic factor Complement-nephritic factor Introduction nephritic factor is an autoantibody to activated C3, it breaks down C3 in the alternate pathway by cleaving it into two fragments that are inactive forms (C3d and C3c) of the normal version of C3b. It binds and stabilises the alternative pathway C3 convertase (that is present in all sera) in the presence and absence of serum proteins. The alternative pathway C3 convertase blocks inhibitors from acting on and destroying C3 convertase.. The autoantibody (the C3 nephritic factor) reacts in the complement system not by blocking the enzyme active site but instead, block the site where inhibitors limit the action of and destroy the enzyme. Tests to determine the C3 nephritic factor are performed in patients that possess a C3 concentration that is below normal and is unexplained, with normal C4 levels [SAS Centre, 2009]. This is because the presence of the C3 nephritic factor in a patient means that C3 is continuously broken down and depleted. Low levels C3 can be associated wi th kidney disorders or recurrent infections. (Chapel et al., 2006) Practical Schedule-The practical schedule is similar to the before mentioned. It used samples with the suspected nephritic factor and other normal serum samples. They are incubated together and if the nephritic factor is present, it breaks down the C3 in the normal sample. (Chapel et al., 2006) Results-As expected from the similarity in methodology the results are similar to the detection of C3 in the picture above using crossed immunoelectrophoesis. If only inactive forms are present owing to inactivation from nephritic factor than the result is deemed positive. A negative result is when there is no nephritic meaning that none of the C3 has been inactivated. Evaluation-This method is useful in the detection of nephritic factor only and it is not a very direct test as it is carried out to determine the amount of C3. Complement-functional assay CH50 Introduction complement functional assay are the basis for the diagnosis of complement deficiency disorders. They are divided into subcategories dependent upon their relation to another disease. Primary complement deficiencies are genetic based and secondary refer to those that are acquired. Functional assays play a pivotal role within the assessment of the classical, alternative and terminal pathway of complement activation. The most common haemolytic assay used within the laboratory setting is the CH50 assay as it is both the simplest and easiest to carry out. The functional integrity of the classical complement pathway, C1, C2, C3, C4 is measured using CH50 along with total haemolytic complement. This is achieved by measuring the required quantity of serum in order to cause haemolysis of half the quantity that had been stabilised and sensitised red blood cells (Chapel et al..2006). Classical components become activated to lyses sheep erythrocytes that are coated in rabbit anti- sheep E antibodies (Rose.. 1997) Practical Schedule Add to microtiter wells the sera to be tested along with a buffer in different concentrations. Then add the sheep erythrocytes. Cover and incubate at 37dgrees for 1 hour. Then centrifuge and carry out ELISA to detect results. (Rose et al., 2002) Results Evaluation- The method is generally sensitive and reliable providing the specimen is tested quickly and all reagents are kept on ice. (Chapel et al., 2006) The problem arises in availability as they are not widely available and as such functional assays for complement are limited to laboratories that have the equipment (Gaspan and Tyring 2008). As with many immunological techniques the fundamental threat to validity is improper sample collection, this can occur easily in the onsite environment where it can be left to stand for considerable periods of time at room temperature. (Rose, 1997) 5. Microbial Antigens ELISA Introduction By coupling the antigen to an insoluble adsorbent it is possible to detect human antibodies to specific antigens using this technique. Elevated levels of antibody titre remains a reliable indication to the presence and measurement of an active infection within the diagnostic process. ELISAs provide highly sensitive and precise methods for the estimation of biological parameters, with the added advantage that they can handle large numbers of samples that may then be analysed rapidly and are useful in detection of a range of viruses and bacterial infections inclusive of TB and pneumonia and viral antigens. (Chapel et al..2006) Many types of immunoassays can be used to detect and quantitative both antigens and antibodies, but there are differences in the avidity requirements for the antibodies, the signal strengths of the labels, and the amount of background for each of these types of assays. Antibody capture assays are the most appropriate for measuring the titre of the antisera you have generated. ELISAs by definition exploit the use of an enzyme attached to one of the reagent utilized in the test. Subsequent addition of the relevant enzyme substrates/ chromogens cause a colour change: the results can be read both by eye and quantified using specially designed spectrophotometers. The fact that proteins (including antibodies) and carbohydrates can be passively attached to plastics has been exploited in most applications of ELISA. Since one of the components is attached to a solid phase by passive absorption, subsequent reagents can be added, and after a period of incubation, unreacted material can be simply washed away. Such assays are termed Heterogeneous ELISAs. The plastic surface is known as the solid phase and plastic in the form of 96-well microtiter plates has proved highly practical for the following reasons. A large number (96) of sample wells are available in a highly practical from; Multichannel pipets (4,8,12 channels) designed for use with such plates are available, making reagent handling rapid and simple; Test volumes are small (e.g. 50uL, 100uL); Comparative readings of coloured products can be made by eye or by specially designed multichannel spectrophotometers (96 wells are read in 2-5s) The above facts afford the potential to rapidly handle numerous plates, and hence numerous samples may be examined, e.g., 20 plates/person= 1920 sample points/ person. Attachment of reagents also allows great versatility for ELISA since the various components of assays may be used in different combinations and in different phases to investigate their potential. It is difficult to generalise about the potential performance of the various ELISA systems. There is a wide range of configurations available and probably no two scientific groups attempting to perform the same task by ELISA will use identical configurations. Practical Schedule Dissolve antigen in carbonate-bicarbonate buffer. Add 200  µl to each well of a micro-ELISA plate cover and incubate overnight at 4 degrees. Wash so that unbound antigen is removed and fill with casein to block remaining binding sites. Incubate at room temperature for 1 hour. Add 200  µl of test serum and incubate for 2 hours at room temperature in a humid chamber. Wash the plate three times Prepare the peroxidase-antibody conjugate, mix 100microlitres of casein with 1 ml of serum, 100 µl Tween 20 with 50  µl peroxidase-antibody and stir gently. Add 200 µl to each well and incubate at room temperature for an hour. Wash three times. Prepare the substrate solution and add200  µl substrate to each well. Leave in the dark and allow colour to develop. Stop the reaction by adding 50  µl of sodium fluoride to each of the wells. An ELISA reader can then be used to quantify the colour reaction. General Method from Hay et al., 2002. Results A positive result would be characterised by the reaction that causes colour showing the presence of antibodies to the specific type of bacteria highlighted by a dark band. Evaluation On the whole this method remains largely specific and rapid. The major cause of problem is the scientist(s) involved. The main problem is the lack of close- contact training in the fundamentals of ELISA, so that the scientist has the experience to identify and then solve the problems in the use of reagents. The results yielded cannot have the biological implications assessed without general knowledge of several field of science, e.g., epidemiology, immunochemistry, biochemistry and immunology. This however should not be considered too problematic as the ELISA should be a tool for the investigation of specific problems rather than an end in itself. Whilst it in comparison to immunoflourence in the detection of TB and flow cytomentry it may lack sensitivity, it does remain the cheapest and easiest to carry out. (Rose et al..1997) 6. Autoantibodies It is becoming increasingly evident that the presence of tissue auto antibodies is not in itself pathognomic of disease. Improvements in the technique in the last few years have led to increased sensitivity and detection of weak antibodies in sera which would hitherto have been reported negative. As a large series of patients are tested in an increasing number of laboratories previously held views on the specific clinical association of particular antibodies are being revised and reference to early literature may therefore be misleading. Since antigens and antibodies are defined by their mutual interactions, they can be used to quantify each other. At a practical level in a diagnostic laboratory, the functional tests are labour intensive and therefore expensive, and a compromise is usually sought by using immunochemical assays which measure composite of medium to high affinity antibodies and their abundance. The antibody has become the scientists flexible friend! For example, antibodies raised against hormones, serum proteins, cell constituents, cytokines, or even immunoglobulins themselves, allow these parameters to be measured in immunoassays. Immunoassays form the backbone of tests used in the study

Sunday, January 19, 2020

Education: United States vs. Ukraine Essay

There are 1.8 million people coming to the United States every year. According to U.S. census estimates, in 2006 there were 961,113 Americans of Ukrainian descent representing 0.33% of the American population. The Ukrainian population in the United States is thus the second largest outside the former Soviet Union. One of the reasons is that the education is more progressive and flexible, which makes it easier for people to attain their educational goals. In different countries and in different cultural environments, education has different forms, methods and meanings for people. Given the opportunity to attend schools in Ukraine and in the United States, I could not help but notice the differences between the two educational systems. The U.S. educational system is more liberal, comprehensive, and specialty focused when compared to the Ukrainian system. The educational system of Ukraine is continuously changing due to the transitional period of the country from the former Soviet Union . During the Soviet period, educational organizations in Ukraine were state-supported institutions, none of which had religious affiliations. As cultural environment changes, this is no longer true for the modern Ukraine. Nowadays, all schools, from pre-school to the institutions of higher education, have Christian classes in their curricular activities. Contrary to the state-sponsored education of the Soviet era, there are both public and private educational establishments, all of which must be accredited by the Ministry of Education of Ukraine. Primary and secondary education comprise pre-school through grade 11. The components of primary level of education are pre-school programs which are attended by two-third of all Ukrainian children. Children ages 6 months to 3 years are enrolled in nursery schools. Children ages 3 to 6 years are enrolled in kindergartens. Then starts secondary education: elementary in grades 1 – 4; lower secondary in grades 5 – 9; and upper secondary in grades 10 – 11. Grades 1 through 9 are collectively called Incomplete (General) Secondary Education, and grades  10 and 11 are called Complete Secondary education. Three types of institutions also offer the upper secondary school curriculum: the general academic schools, the secondary vocational-technical schools and the specialized secondary school. Regardless of the type of upper secondary training completed, Ukrainian students have the right to continue their education at a postsecondary institution. Applications are accepted from citizens who meet the following criteria: * students have completed secondary education; * for full-time study students must be under 35 years of age and there are no age limits for part-time or evening study; * students have passed a competitive entrance examination set by each institution of higher education. There are three types of grading systems in Ukraine. Ordinarily universities used a traditional 5-point scale: â€Å"5† = â€Å"excellent†, â€Å"4† = â€Å"good†, â€Å"3† = â€Å"acceptable†, â€Å"2† = â€Å"unacceptable†. Since 2006, university students are graded on a rating scale of 0 to 100. These grades can be transformed to the 5-point scale approximately as follows: from 91 to 100 means â€Å"5†, from 71 to 90 means â€Å"4†, from 51 to 70 means â€Å"3†, from 0 to 50 means â€Å"2†. Both the rating scale and the 5-point scale are used in university registers at the present. As for secondary schools, they also used the 5-point scale until 2000. Since 2000 secondary schools use a 12-point scale, which could be transformed into the traditional 5-point scale as follows: â€Å"12† = â€Å"5+†, â€Å"11† = â€Å"5†, â€Å"10† = â€Å"5-† and so on. Education in the United States follows a pattern similar to that in the Ukrainian system. Early childhood education is followed by elementary school, middle school, high school, and then postsecondary education. Postsecondary education includes non-degree programs that lead to certificates and diplomas plus six degree levels: associate, bachelor, first professional, master, advanced intermediate, and research doctorate. The U.S. system does not offer a second or higher doctorate, but does offer postdoctorate research programs. Contrary to the Ukrainian system, in the United States people can go to college at any age and also have homeschooling programs. The most common grade scale in the United States is the letter grade: â€Å"A† through â€Å"F†, which is derived from a scale of 0–100 points. The following table shows the transformation: A| B| C| D| F| | | –| | | –| | | –| | | –| | 100-97| 96-93| 92-90| 89-87| 86-83| 82-80| 79-77| 76-73| 72-70| 69-67| 66-63| 62-60| Below 60 Percent| One of the big differences between two systems is course schedule. In Ukraine students have to follow a particular schedule made to satisfy the educational institution program, while in the United States students have flexibility in scheduling their classes. For example, if I start any level of secondary or postsecondary education in Ukraine, I will be assigned to a group of 20-30 people (called a â€Å"class†), who have the same schedule and we don’t have to register for any classes, because everything is already prepared for us. Nowadays, in US I make my own schedule that satisfies my choice of degree requirements and my work hours. Another big difference is the availability and accessibility of technology to students. In Ukraine, schools and colleges are very underfunded which results in poor or no equipment. Students in Ukraine do not have as many resources as students in the United States have, unless they come from wealth. Some people say that lack of technology lowers the quality of education. I believe the use of technology is helpful, has a significant positive effect on students and is just more fun; however it does not affect the quality of education. Taking into consideration all the similarities and differences of both educational systems, the Ukrainian system dictates to students each step of the educational process, while the US system is more flexible, provides more freedom and advanced technology. Overall, learning in the United States is a great opportunity that not everyone has. Thus, those who have it should make the most of the chance to learn.

Saturday, January 11, 2020

Leonardo da Vinci in our life

Leonardo dad Vine's contribution to the era of Renaissance The Renaissance era created an immense amount of talented scientists, artists, inventors, and philosophers who contributed great deal to the development of human race. In history it is hard to find a similar genius individual as the creator of High Renaissance art – Leonardo dad Vinci. Even aftereffects of research on his creations, we are still captivated by the brilliance of his works. Leonardo dad Vinci was an artist, a sculptor, an architect, a philosopher, a historian, a mathematician, a physicist, a mechanic, and an astronomer. Consider Leonardo a genius of the High Renaissance.He was undeniably way ahead of his time, and is undoubtedly one of desegregates geniuses that ever lived. He played an enormous role in the development of art and science of the High Renaissance in Italy. His creations â€Å"Last Supper† (495-97) and â€Å"Mona Lisa† (1503-06) are among the most widely popular art works of th e Renaissance. The â€Å"Mona Lisa† painting is a good example of his work which contributed to the development of art in the Renaissance. The Mona Lisa is a portrait of a wife of a Florentine noble. She refused to smile; Leonardo even tried ring musicians but that didn't change her mind.At last, Just for a second she smiled faintly and Leonardo was able to capture it. In his drawing Leonardo masters the techniques of Suffuse and Chiaroscuro. Suffuse involves the most gradual transition from one color to another, giving it a very delicate and expressive image. As mentioned in the studies, Chiaroscuro highlights the contrast of light and shadow. In the Mona Lisa, this is most evident in the contrast between the face and the dark background. I consider the â€Å"Mona Lisa† his most beautiful creation. Leonardo dad Vinci highly influenced the development of science of the High Renaissance in Italy.He is considered one of the prominent contributors to the scientific discov eries of the era. Dad Vinci extended his studies into science and other subjects. For example, he drew complex models of flying machines, as he was fascinated by flight. He also attempted to build flying objects himself and designed an immense amount of mechanical devices. Based on his studies of birds, he drew a human powered ornithology, which is a wing flapping machinate would fly, mimicking the movement of a bird in flight. As a result, some of the machines that he drew on paper such as helicopters would become reality many centuries later.He also had knowledge in the studies of anatomy and was one of the first to understand the circulation of blood in the human body. There seemed to be no limit to his interests and work. Leonardo dad Vinci is one the most prominent individualists lived in the Renaissance era and contributed a vast amount of scientific discoveries and beautiful works of art which are genius and timeless. Leonardo looked far ahead of his time and influenced our g eneration and development of the modern world today. Leonardo dad Vinci in our life By Andrews

Friday, January 3, 2020

Making Sure Your Internet is Safe From Hackers 2019

There has been an astonishing proliferation of Internet connected computers in the last decade. Huge numbers of businesses and individuals are hooked up and able to access information and use information technology available worldwide. Along with the benefits, however, this technology brings come some definite risks. Unauthorized parties can easily access the information on your computer unless protective measures are taken. Studies show that it is fairly easy to gain unauthorized access to information in an insecure networked environment, which is how most of us operate. It is extremely difficult to catch intruders. A report published in 1997 by CERT (a registered trademark from Carnegie Mellon Institute) details the types of security breaches and makes it clear that nobody is immune from computer abuse. It happens at banks, insurance companies, hospitals, and private homes. When this report was published, the statistics showed that there were only 100 security incidents involving computers in 1988 and, by 1995, there had been 2,500. Obviously there is exponential growth in this situation from 1995 to the present day. .ue4009ad57dcec8505036b08fa5f4dfa3 { padding:0px; margin: 0; padding-top:1em!important; padding-bottom:1em!important; width:100%; display: block; font-weight:bold; background-color:#eaeaea; border:0!important; border-left:4px solid #34495E!important; box-shadow: 0 1px 2px rgba(0, 0, 0, 0.17); -moz-box-shadow: 0 1px 2px rgba(0, 0, 0, 0.17); -o-box-shadow: 0 1px 2px rgba(0, 0, 0, 0.17); -webkit-box-shadow: 0 1px 2px rgba(0, 0, 0, 0.17); text-decoration:none; } .ue4009ad57dcec8505036b08fa5f4dfa3:active, .ue4009ad57dcec8505036b08fa5f4dfa3:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; text-decoration:none; } .ue4009ad57dcec8505036b08fa5f4dfa3 { transition: background-color 250ms; webkit-transition: background-color 250ms; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; } .ue4009ad57dcec8505036b08fa5f4dfa3 .ctaText { font-weight:bold; color:inherit; text-decoration:none; font-size: 16px; } .ue4009ad57dcec8505036b08fa5f4dfa3 .post Title { color:#000000; text-decoration: underline!important; font-size: 16px; } .ue4009ad57dcec8505036b08fa5f4dfa3:hover .postTitle { text-decoration: underline!important; } READ Find Science and Engineering Degree ProgramsOne of the biggest news stories regarding security was recently reported on eWeek.com. This story details a vulnerability in Apple Computers Safari Web browser and worms that target the OS X operating system. This obviously affects computers not running on the Windows operating system. What can you do to protect yourself? There are several methods used to make data safer on home and business computers. Passwords, access control files and keys, and encryption algorithms are often used to minimize the risk of intrusion. Several products are offered online which can help individuals and businesses assess their computer intrusion risk. Janco Associates, Inc. produces a security manual that is 178 pages in length. It includes a questionnaire to establish the threat and vulnerability to your computer system. Part of this service is an update to the manual for 18 months, as new risks are introduced into the online highway. .u768a028c7f213d6d8cafcdbffc57fee9 { padding:0px; margin: 0; padding-top:1em!important; padding-bottom:1em!important; width:100%; display: block; font-weight:bold; background-color:#eaeaea; border:0!important; border-left:4px solid #34495E!important; box-shadow: 0 1px 2px rgba(0, 0, 0, 0.17); -moz-box-shadow: 0 1px 2px rgba(0, 0, 0, 0.17); -o-box-shadow: 0 1px 2px rgba(0, 0, 0, 0.17); -webkit-box-shadow: 0 1px 2px rgba(0, 0, 0, 0.17); text-decoration:none; } .u768a028c7f213d6d8cafcdbffc57fee9:active, .u768a028c7f213d6d8cafcdbffc57fee9:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; text-decoration:none; } .u768a028c7f213d6d8cafcdbffc57fee9 { transition: background-color 250ms; webkit-transition: background-color 250ms; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; } .u768a028c7f213d6d8cafcdbffc57fee9 .ctaText { font-weight:bold; color:inherit; text-decoration:none; font-size: 16px; } .u768a028c7f213d6d8cafcdbffc57fee9 .post Title { color:#000000; text-decoration: underline!important; font-size: 16px; } .u768a028c7f213d6d8cafcdbffc57fee9:hover .postTitle { text-decoration: underline!important; } READ Computer Science Related CareersMicrosoft offers security updates for Windows users. Window Defender scans your system to remove unwanted software. Microsofts website offers tools and tips on how to scan and clean your computer to rid it of unwanted information that can damage your systems and result in a loss of information. There are products available like Symantec AntiVirus (which Gateway calls its best deal) to clean up security issues. Any software product with anti-virus in its name is probably a safe bet. We are in an age of incredible computer technology, but as more and more people avail themselves of this privilege, the risk of intrusion is increased. Dont let your information fall into the wrong hands. Take steps to protect yourself today. Related ArticlesThe Academics of Information TechnologyFrom IT School to an IT CareerUnderstanding Computer ScienceBusiness Administration Careers You Should ConsiderThe Information Technology IndustryWebsites Helping Small Business .u9c950070756286232da5bf9b8a9f78f2 { padding:0px; margin: 0; padding-top:1em!important; padding-bottom:1em!important; width:100%; display: block; font-weight:bold; background-color:#eaeaea; border:0!important; border-left:4px solid #34495E!important; box-shadow: 0 1px 2px rgba(0, 0, 0, 0.17); -moz-box-shadow: 0 1px 2px rgba(0, 0, 0, 0.17); -o-box-shadow: 0 1px 2px rgba(0, 0, 0, 0.17); -webkit-box-shadow: 0 1px 2px rgba(0, 0, 0, 0.17); text-decoration:none; } .u9c950070756286232da5bf9b8a9f78f2:active, .u9c950070756286232da5bf9b8a9f78f2:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; text-decoration:none; } .u9c950070756286232da5bf9b8a9f78f2 { transition: background-color 250ms; webkit-transition: background-color 250ms; opa city: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; } .u9c950070756286232da5bf9b8a9f78f2 .ctaText { font-weight:bold; color:inherit; text-decoration:none; font-size: 16px; } .u9c950070756286232da5bf9b8a9f78f2 .postTitle { color:#000000; text-decoration: underline!important; font-size: 16px; } .u9c950070756286232da5bf9b8a9f78f2:hover .postTitle { text-decoration: underline!important; } READ The Path to Teaching A Bachelor's Degree in Education